inglés al español Medicina Medicina (general)

Estoy traduciendo un artículo titulado: "An evaluation of engraftment, toxicity and busulfan concentration in children receiving bone marrow transplantation for leukemia or genetic disease".

"Regimen-related toxicity (RRT) was evaluated using BMT criteria described by Bearman et al during the first 28 days post transplant and assigned a grade of 1 to 4. Engraftment was defined as an absolute ANC greater than 500 for 3 consecutive days with evidence of donor cells either by PCR for non-HLA DNA polymorphisms and/or in situ hybridization for X and Y chromosomes in sex-mismatched transplants. A quantitative estimate of engraftment (percent donor cells) was provided for sex-mismatched transplants. For **non-HLA DNA assays**, unique donor and recipient alleles were identified to assess full donor chimerism (sensitivity of 1–5%). For analysis, we included as ‘engrafted’ only those patients with 100% donor chimerism. Primary graft rejection was defined as no evidence of donor cells; secondary rejection was documented by initial evidence of donor engraftment followed by full autologous recovery. Engraftment was evaluated at 3 month intervals up to 1 year post BMT."

BMT = bone marrow transplant = trasplante de médula ósea
HLA = Human leukocyte antigens = antígenos leucocíticos humanos y se usan para determinar la compatibilidad entre donante y receptor de un trasplante
DNA = ADN

Muchas gracias nuevamente