Jan 17, 2016 00:08
8 yrs ago
12 viewers *
English term
non-HLA DNA assays
English to Spanish
Medical
Medical (general)
Estoy traduciendo un artículo titulado: "An evaluation of engraftment, toxicity and busulfan concentration in children receiving bone marrow transplantation for leukemia or genetic disease".
"Regimen-related toxicity (RRT) was evaluated using BMT criteria described by Bearman et al during the first 28 days post transplant and assigned a grade of 1 to 4. Engraftment was defined as an absolute ANC greater than 500 for 3 consecutive days with evidence of donor cells either by PCR for non-HLA DNA polymorphisms and/or in situ hybridization for X and Y chromosomes in sex-mismatched transplants. A quantitative estimate of engraftment (percent donor cells) was provided for sex-mismatched transplants. For **non-HLA DNA assays**, unique donor and recipient alleles were identified to assess full donor chimerism (sensitivity of 1–5%). For analysis, we included as ‘engrafted’ only those patients with 100% donor chimerism. Primary graft rejection was defined as no evidence of donor cells; secondary rejection was documented by initial evidence of donor engraftment followed by full autologous recovery. Engraftment was evaluated at 3 month intervals up to 1 year post BMT."
BMT = bone marrow transplant = trasplante de médula ósea
HLA = Human leukocyte antigens = antígenos leucocíticos humanos y se usan para determinar la compatibilidad entre donante y receptor de un trasplante
DNA = ADN
Muchas gracias nuevamente
"Regimen-related toxicity (RRT) was evaluated using BMT criteria described by Bearman et al during the first 28 days post transplant and assigned a grade of 1 to 4. Engraftment was defined as an absolute ANC greater than 500 for 3 consecutive days with evidence of donor cells either by PCR for non-HLA DNA polymorphisms and/or in situ hybridization for X and Y chromosomes in sex-mismatched transplants. A quantitative estimate of engraftment (percent donor cells) was provided for sex-mismatched transplants. For **non-HLA DNA assays**, unique donor and recipient alleles were identified to assess full donor chimerism (sensitivity of 1–5%). For analysis, we included as ‘engrafted’ only those patients with 100% donor chimerism. Primary graft rejection was defined as no evidence of donor cells; secondary rejection was documented by initial evidence of donor engraftment followed by full autologous recovery. Engraftment was evaluated at 3 month intervals up to 1 year post BMT."
BMT = bone marrow transplant = trasplante de médula ósea
HLA = Human leukocyte antigens = antígenos leucocíticos humanos y se usan para determinar la compatibilidad entre donante y receptor de un trasplante
DNA = ADN
Muchas gracias nuevamente
Proposed translations
(Spanish)
2 | ensayos con muestras de ADN para detección/presencia de anticuerpos anti-HLA | Margarita Ezquerra (Smart Translators, S.L.) |
Proposed translations
12 hrs
Selected
ensayos con muestras de ADN para detección/presencia de anticuerpos anti-HLA
No estoy segura, pero creo que por aquí van los tiros. Prefiero que lo investigues bien o esperar a recibir otras aportaciones.
Espero te sirva de algo. Saludos y feliz domingo.
Espero te sirva de algo. Saludos y feliz domingo.
4 KudoZ points awarded for this answer.
Comment: "Gracias. Al final coloqué: análisis de ADN que no sea de los antígenos de histocompatibilidad"
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