English to French Medical Medical: Pharmaceuticals immunothérapie

Summary of overcoming toxicities by the suicide gene co-expression in T cells. (a) HSV-tk turns the nontoxic prodrug GCV into GCV-triphosphate, leading to cell death by halting DNA replication. (b) iCasp9 can bind to the small molecule AP1903 and result in dimerization, which activates the intrinsic apoptotic pathway.